CD106间充质干细胞独特的免疫调节特性
文章报道来源于绒毛、骨髓、脐带、脂肪的间充质干细胞表达CD106(VCAM-1)水平依次降低，并且CD106+与CD106-的绒毛间充质干细胞的生物学特性有差异，虽分化能力相似，但在集落形成能力和对T辅助细胞效应不同。
延伸：间充质干细胞是目前干细胞研究的热点，常见的分类主要是细胞来源例如骨髓间充质干细胞，脂肪间充质干细胞，肌肉间充质干细胞等等，对其使用意义缺少指导意义。本文利用细胞表面分子CD106对间充质干细胞进行分类，并分析其生物功能，对于间充质干细胞实际应用具有现实意义。
PLoS One. 2013;8(3):e59354. doi: 10.1371/journal.pone.0059354. Epub 2013 Mar 12.
CD106 identifies a subpopulation of mesenchymal stem cells with unique immunomodulatory properties.
Yang ZX, Han ZB, Ji YR, Wang YW, Liang L, Chi Y, Yang SG, Li LN, Luo WF, Li JP, Chen DD, Du WJ, Cao XC, Zhuo GS, Wang T, Han ZC.
The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin, China.
Abstract
Mesenchymal stem cells (MSCs) reside in almost all of the body tissues, where they undergo self-renewal and multi-lineage differentiation. MSCs derived from different tissues share many similarities but also show some differences in term of biological properties. We aim to search for significant differences among various sources of MSCs and to explore their implications in physiopathology and clinical translation. We compared the phenotype and biological properties among different MSCs isolated from human term placental chorionic villi (CV), umbilical cord (UC), adult bone marrow (BM) and adipose (AD). We found that CD106 (VCAM-1) was expressed highest on the CV-MSCs, moderately on BM-MSCs, lightly on UC-MSCs and absent on AD-MSCs. CV-MSCs also showed unique immune-associated gene expression and immunomodulation. We thus separated CD106(+)cells and CD106(-)cells from CV-MSCs and compared their biological activities. Both two subpopulations were capable of osteogenic and adipogenic differentiation while CD106(+)CV-MSCs were more effective to modulate T helper subsets but possessed decreased colony formation capacity. In addition, CD106(+)CV-MSCs expressed more cytokines than CD106(-)CV-MSCs. These data demonstrate that CD106 identifies a subpopulation of CV-MSCs with unique immunoregulatory activity and reveal a previously unrecognized mechanism underlying immunomodulation of MSCs.
